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  • Center for hyperbaric oxygen therapy (HBOT) and diving medicine

Research at the HBO-Zentrum Euregio Aachen

ID-100220946Working in close cooperation of the Aachen university clinic and the RWTH Aachen, our hyperbaric pressure chamber centre provides the facilities for not only treating patients with hyperbaric medicine but also for basic research and clinical research.

  • Influence of hyperbaric oxygen therapy on cardiac function

    The influence of hyperbaric oxygen therapy on cardiac function: major changes to atmospheric pressure have an influence on the cardiovascular system. The use of impedance cardiography allows analysis of the changes experienced by the heart function during exposure to different pressures. This project is in partnership with the Helmholtz institute of the RWTH Aachen.

    Contact: Dr. med. T. Janisch

  • Influence of hyperbaric oxygen therapy on microcirculation

    Good capillary circulation is essential in particular for the treatment of problem wounds. A microscopic camera is used to analyse the influence of HBO therapy on capillary circulation.

    Contact: Dr. med. T. Janisch

  • Influence of hyperbaric oxygen therapy on immunological processes

    HBO therapy has an effect on the human immune system. Biochemical analysis methods are intended to analyse immunological processes triggered by HBO therapy to better understand the processes involved.

    Contact: Dr. med. T. Janisch

  • Evaluation of microcirculation of the foot by mapping measurement points under the influence of hyperbaric oxygenation (HBO)

    Adequate perfusion of tissues is a prerequisite for satisfactory healing of wounds, in particular in the case of fractures of the foot and Achilles tendon injuries. The high rate of wound healing process disorders, infections and pseudo-arthrosis reflects on restrictions often present in microcirculation in the area of injury. This is due to a limited anatomical vascular circulation of the tarsal bones as well as resulting tissue damage (dislocation, haemorrhage, oedema, contamination etc.) and is furthermore influenced by individual patient factors and surgically-related trauma.

    The use of hyperbaric oxygen therapy in treatment and follow-up treatments is therefore considered as very promising because of its many positive effects. However, little is known on the precise impact of HBO on microcirculatory parameters.

    In order to evaluate the circulation of blood in the foot and the influence of hyperbaric oxygen on microcirculation, it is intended to prepare the mapping of specific measurement points of a healthy foot.

    By using the O2C unit (laser Doppler / white light spectroscopy: “oxygen to see”; LEA Medizintechnik GmbH), measurements are intended on the microcirculatory parameters of 40 healthy volunteers. Items to be considered are the oxygen saturation of haemoglobin, relative haemoglobin numbers, relative blood flow and blood flow velocity. A special area of interest are anatomically defined segments of the calcaneus and the talus, the Achilles tendon and soft tissue areas, which need to be incised for common calcaneus access paths (lateral L-incision, Palmer, McReynolds). The study makes use of a surface probe (2 mm and 8 mm depth) and a deep probe (15 mm depth). In total 31 measuring points are recorded on the right foot.

    The objective is to identify standard values for microcirculation based on a series of native measurements. This will then provide the basis for future early detection of threatening or existing wound complications in order to allow therapy. In addition, limits would be available to help identify the best access path for surgical intervention on a case-by-case basis.

    In order to be in the position to investigate the influence of HBO treatment on microcirculation (initially on volunteers, later on patients), a second series is planned directly after HBO treatment (90 minutes at 1.4 bar hyperbaric pressure).

    Contact: PD Dr. med. M. Knobe, Klinik für Unfallchirurgie Uniklinik RWTH Aachen






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Centre for hyperbaric oxygen therapy (HBOT) and diving medicine